What is the difference between String and string

string is an alias for System.String. So technically, there is no difference. It's like int vs. System.Int32.

As far as guidelines, I think it's generally recommended to use string any time you're referring to an object. e.g.

string place = "world";

Likewise, I think it's generally recommended to use String if you need to refer
specifically the class. e.g.

string greet = String.Format("Hello {0}!", place);